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Description

Multiple effects mediate this feedback (Figure 5), including: inhibition of POMC transcription (as outlined above)

Clinical trials have documented gastrointestinal adverse effects as the most common side effects of GLP-1 medicines

[Google Scholar] 26.Zhou GH, Pao YC, Lu JM

Renal: Recommendation 9.11 supports initiation and continuation of GLP-1-based therapy in advanced CKD, expanding therapeutic options for this high-risk population

Insulin acts directly on the vascular tissue, including endothelial cells (111), and smooth muscle cells (112)