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The Nrf2sMAF heterodimer binds to the antioxidant response element (ARE), which leads to the transcription of genes encoding antioxidant and detoxification enzymes such as SOD, CAT, GP X , heme oxygenase 1 (HO-1), NAD(P)H quinone dehydrogenase 1 (NQO1), which protect cells from oxidative stress and toxins (124126) (Figure 3)
demonstrated that febuxostat treatment to reduce serum uric acid levels tended to reduce renal functional deterioration in patients with both CKD and hyperuricemia
Amino acid metabolism primarily supports the resynthesis of cellular components or the synthesis of bioactive substances, such as enzymes and hormones
Berglund, E
Recovery time from B12 deficiency varies depending on the severity and underlying cause
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