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showed that increased TMAO levels were a risk factor for MACEs at 30 days and 6 months in patients presenting with chest pain of suspected cardiac origin

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Neuroendocrine dysfunction in gamma-aminobutyric acid (GABA) signaling and neuronal androgen receptors that might alter hypothalamic sensitivity and lead to an impairment of estradiol and progesterone feedback

In the studies, L-carnitine administration ranged from 0.54 g/day to 2.4 g/day on average across studies