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The CES enzymes also metabolize a wide range of xenobiotic substrates, including heroin, which is metabolized by sequential deacetylation (phase I reaction) to 6-monoacetylmorphine (6-MAM) and morphine

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For example, the Food and Drug Administration recently approved Novo Nordisks application to add cardiovascular benefits to Wegovys label

The combination is thus a prime example of the strategy of combining two complementary satiety signals rather than simply stimulating a single receptor pathway more strongly

The biggest concern comes from allergic reactions, which can range from mild skin rashes to severe breathing problems that need immediate medical care