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The disconnect between this promising science and clinical application is stark: not a single human trial exists for mental health applications, leaving patients and clinicians with compelling mechanisms but zero human efficacy or safety data
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doi: 10.1024/0300-9831/a000623 9
[Google Scholar] Kawano M, Takagi R, Kaneko A, Matsushita S (2015) Berberine is a dopamine D1- and D2-like receptor antagonist and ameliorates experimentally induced colitis by suppressing innate and adaptive immune responses
The presence of fibrinogen, a protein that does not usually cross the BBB, can activate microglia and promote neuroinflammation, leading to cognitive decline and mood disturbances [193]
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