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Therefore, a novel composite system integrating soluble microneedles with targeted nanoparticlestermed a nanoparticle-microneedle delivery platformholds significant potential for effective and sustained treatment of RA

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Notably, administration of GEP44 resulted in an 80% reduction in food intake and a more profound loss of body weight than what could be achieved in response to treatment with several of the US Food and Drug Administration (FDA)-approved GLP-1RAs, including Ex-4 and liraglutide (LIRA)

Additionally, some companies are researching ways to reduce further adverse effects, such as developing co-formulated anti-nausea compounds to improve tolerability ." Future research for GLP-1 therapies presents numerous possibilities