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3.1.5 Chronic rhinosinusitis without nasal polyps Chronic rhinosinusitis (CRS), defined by chronic inflammation of the paranasal sinuses, is a common comorbidity in individuals with chronic lower respiratory conditions, such as COPD, bronchiectasis, CF, and asthma (126129)

Bremelanotide is essentially a refined metabolite of melanotan II, designed to maximize sexual effects while minimizing side effects

While TMAOs pro-atherogenic mechanisms are well-characterized in other diseases (112118), its specific role in SLE-related cardiovascular complications requires cautious interpretation given the limited disease-specific evidence

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