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This compound undergoes hepatic metabolism via monoamine oxidase (MAO) and sulfation pathways, with primary clearance occurring through renal excretion
The recently published randomised controlled Study of Tirzepatide Compared with Dulaglutide on Major Cardiovascular Events in Participants With Type 2 Diabetes (SURPASS-CVOT) demonstrated that tirzepatide (up to 15 mg) was non-inferior to dulaglutide (1.5 mg) in reducing major adverse cardiovascular events (death from cardiovascular causes, myocardial infarction or stroke) in patients with T2DM and atherosclerotic CVD
4,5 The main hormones that regulate metabolic homeostasis are insulin and glucagon, which are secreted into circulation as required by islet-beta and alpha cells, respectively
Statistical significance was determined by two-tailed unpaired t -test
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