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Although direct studies specifically linking BET inhibitors to HIF suppression are still emerging, existing literature acknowledges that BET bromodomain inhibition can suppress transcriptional programs driven by HIF and other oncogenic transcription factors (208)

While some do support healthy gut function, very few are engineered with specific attention to weight management goals

Time course experiments were performed using a single ligand concentration to determine the peak response time point (3min) for the subsequent concentration response curves as previously described

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