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On the other hand, Langerhans cells are increased in the epidermis, the basement membrane is thickened, and cytoplasmic vacuolization phenomena are observed.44,45 It should be noted that Dickkopf 1 (DKK1) protein, involved in reducing melanogenesis, is overexpressed in fibroblasts in lesional skin.46 There is also increased fibronectin expression and reduced elastin in lesional dermis, with no changes observed in collagen fibers.47,48 Genetic changes involved in the etiopathogenesis of vitiligo Vitiligo is a complex disease with a significant genetic component, estimated between 75% and 83%

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The same happens with vitamin C glutathione recycles it and extends its antioxidant capabilities through the glutathione-ascorbic acid cycle

controlled human efficacy evidence is lacking and individual results vary

43 , e47e47 (2015)