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At the highest dose tested, participants in the retatrutide group achieved mean body weight reductions of approximately 24% a figure that exceeded results previously reported for single-agonist (semaglutide) and dual-agonist (tirzepatide) compounds at comparable trial stages

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Muscle is heavier than fat and metabolically active, meaning it requires more energy simply to sustain it, says Tonya Prather, NASM-CPT, a certified personal trainer and Fitness Director at The Nelson Golf & Sports Club in Irving, Texas