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Digestive Issues Women with Lipedema already have higher rates of: IBS Constipation Bloating SIBO (small intestinal bacterial overgrowth) Slow digestion GLP-1s slow gastric emptying even further, which can increase: Constipation Gastroparesis Reflux Nausea If digestive issues are present, they ideally should be addressed before starting GLP-1s

In 2024, a comprehensive systematic review found evidence to suggest the benefits of fasting, including IF, in reducing the population risk of cardiovascular disease

There are also safety considerations

Bitter orange powder provides synephrine, a natural compound that may enhance metabolic rate and support appetite control