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T.ZhouF.VallabhaneniH.et al

False positives were minimized using predefined filtering criteria, and data were normalized using internal standards specific to different lipid classes

Investigators used the TriNetX multi-institutional database to identify patients based on ICD-10 codes

Nutrition & metabolism , 13 , 1-16

During development and progression of atherosclerosis, Nrf2 signaling modulates many physiological and pathophysiological processes, like regulation of lipid homeostasis, CD36 gene expression regulation, foam cell formation, macrophage polarization, immunity regulation (Th2 differentiation and inhibition of pro-inflammatory gene expression through NFB down-regulation), redox regulation and inflammation, improvement of endothelial dysfunction, as well as GSH synthesis and utilization (234245)