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Biol Psychiatry 64:46875

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Fu, Y., Sander, J

Mechanism of Action: qualitatively similar to dextroamphetamine compared to amphetamine, the methyl side group present in methamphetamine results in a higher lipid solubility, greater penetration of the blood brain barrier, higher potency with respect to dopamine release, longer half life, and higher potential for abuse and neurotoxicity due to oxidative stress (Yamamoto & Raudensky, 2008