Combination therapy can add complexity because semaglutide has its own GI side-effect profile, and overlapping appetite and gastric-emptying effects can be clinically meaningful
Antonini A, Emmi A, Campagnolo M
Fajersztajn L, Veras M, Barrozo LV, Saldiva P
Tirzepatide has not been studied specifically for osteoarthritis outcomes in a dedicated trial, though weight loss from any intervention typically improves joint pain
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