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In an acute study, semaxinib treatment led to significant clinical improvement, with less demyelination and cellular infiltration in the spinal cord

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The three compounds, in a rigorous research approach, require: strict analytical control (MS + HPLC 98%), adapted administration route (intranasal for BBB crossing), standardised behavioural model with positive control, and exhaustive documentation for publication

Prior to the analyses shown here, the BMD 50 was estimated in addition to the BMD 100 to compare different critical effect sizes for ranking of NAs (data not shown)

Declarations Competing Interests The authors declare no competing interests