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Since N-terminal sequences of AsGGT1, AsGGT2, and AsGGT3 are long and may contain the signal sequence for secretion or targeting to cellular organelles, three types of fusion proteins, GFP C-terminally fused to the N-terminal 100-amino acid residues of GGT (AsGGT1 N100 -GFP, AsGGT2 N100 -GFP, and AsGGT3 N100 -GFP), GFP C-terminally fused to the N-terminal 300-amino acid residues of GGT (AsGGT1 N300 -GFP, AsGGT2 N300 -GFP, and AsGGT3 N300 -GFP), and GFP C-terminally fused to the full-length GGT protein (AsGGT1 Full -GFP, AsGGT2 Full -GFP, and AsGGT3 Full -GFP), were analyzed
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For example, Novo Nordisk's CagriSema, a combination of semaglutide and cagrilintide, has shown superior results in lowering blood sugar and promoting weight loss compared to semaglutide alone