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Semax, a heptapeptide derived from ACTH (4-10) , has been investigated through proposed BDNF-mediated and neuroprotective mechanisms in cerebral ischemia and cognitive models

There are other intrinsic (genetic) and extrinsic (environmental) factors viz

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Crit Rev Plant Sci 27(5):342375 Ehrlich M (2019) DNA hypermethylation in disease: mechanisms and clinical relevance

Even other components such as collagen and elastin are activated