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A selective non-competitive inhibitor of VMAT2 VMAT1 is a different isoform expressed in peripheral neuroendocrine cells (adrenal chromaffin cells, interneurons of sympathetic ganglia, and enterochromaffin cells that store serotonin in the GI tract)

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Such a situation may have rendered this group of population even more susceptible to SARS-CoV2 at the time of its spreading