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Some may have trouble sleeping if they take it too late in the day, as it can overexcite the body via the methylation pathway

Gentle mixing by rolling the vial between the hands may be appropriate if settling has occurred, but aggressive agitation should be avoided

Key Takeaways Vitamin B12 deficiency is widespread and is often dietary or malabsorption-induced Sometimes low levels of B12 can be an indication of more serious problems, such as some cancers Complications are prevented by early testing and appropriate medical treatment CKS Hospital has all-around care of diagnosis, care, and nutrition Frequently Asked Questions (FAQs) Q1

10.1007/s12035-015-9639-7 137 YuP.WangL.TangF.GuoS.LiaoH.FanC.et al (2021)

Drug interactions: Certain medications, such as omeprazole, lansoprazole, cimetidine, and metformin, can lead to low vitamin B12 levels