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The available evidence indicates that there is a notable impairment in endothelial-derived nitric oxide (NO)-mediated vasodilation in individuals with both insulin-dependent and non-insulin-dependent diabetes mellitus (91)

doi: 10.1038/s41598-019-39060-1 94 Ortega-HernandezODShoenfeldY

Accordingly, taking advantage of complementary mechanisms of action with the combined use of these two classes of agents to further improve cardiorenal outcomes is conceptually appealing, but has yet to be explored in detail in clinical trials

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Developmental regulation and individual differences of neuronal H3K4me3 epigenomes in the prefrontal cortex