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Figure 3 Figure 4 As also underlined by the WHO Working Group in a paper published shortly after the 2018 Classification, the risk of an individual nevus progressing to melanoma has been estimated to be in the order of one in 33,000 or less per year (60)

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The authors claimed the size change could promote the passive targeting via leaking vasculature (7150 nm) and meanwhile prevent homogenous leakage of SPIONs into normal tissues

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This risk is very real