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Bariatric surgery, sometimes referred to as metabolic surgery, is usually considered for patients who have a BMI 40 kg/m 2 or a BMI 35 kg/m 2 associated with comorbidities such as type 2 diabetes ( Observational and prospective studies have suggested that bariatric surgery is the most effective intervention for weight loss producing an average weight loss of 3035% that is maintained in ~60% of patients at 5 years (7)

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Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice