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In contrast, GLP-1 receptor agonists approved by the FDAincluding semaglutide (Ozempic, Wegovy), dulaglutide (Trulicity), liraglutide (Victoza, Saxenda), and tirzepatide (Mounjaro, Zepbound, which also activates GIP receptors)are modified to resist DPP-4 degradation
in this model gliadin triggers zonulin release, which loosens the junctions and raises permeability [8]
GLP-1 medications reduce appetite and slow gastric emptying, which often creates a significant calorie deficit in the early weeks of treatment
It also regulates the activation of neural stem cells, cognition, synaptic formation, and neuronal apoptosis
Contraception : Women of childbearing potential should use non-oral contraception or backup methods for 4 weeks after tirzepatide initiation and after each dose escalation
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