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On the question of Epitalon experience in humans, a Russian clinical programme exists that was carried out over years with Epithalamin and related pineal peptides

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Clinical diagnosis of organic acid metabolism disorders can be assisted by gas-liquid chromatography examination of organic acids and their derivatives in urine and blood, and other auxiliary diagnostic methods include electroencephalogram, cranial nuclear magnetic resonance, enzyme analysis, and genetic testing, etc

The neurological symptoms, in particular, can become permanent if left untreated long enough

The p -values and significance levels are included in the figure and table legends