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Some practitioners implement cycling to theoretically prevent receptor desensitization, provide physiological breaks, or manage costs, though evidence supporting these approaches is limited
While very high oral doses (1,000 to 2,000 mcg) can achieve some passive absorption without intrinsic factor roughly 1% of the dose is absorbed passively many clinicians prefer the reliability and rapid correction offered by injections in this population
It also helps to reduce the risk of developing heart attack, dementia, and stroke, since it decreases homocysteine levels
The frequency of B12 injections depends on individual needs and the severity of the deficiency
Taking vitamin B5 together with antibiotic tetracycline will interfere with the absorption and effectiveness of these antibiotics
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