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doi: 10.3389/fimmu.2017.01077 48 WijayalathWMajjiSVillasanteEFBrumeanuTDRichieTLCasaresS

Zhu et al., 2018)

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These cytokines can alter the balance between excitatory and inhibitory neurotransmission, leading to the synaptic dysfunction characteristic of depression

Figure 2 illustrates how proinflammatory cytokines influence the kynurenine pathway, thereby affecting neurotransmitter metabolism and contributing to neuroinflammation, cognitive dysfunction, and neurodegeneration