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Side effects are typically mild and temporary, especially as your body adjusts: nausea, constipation or diarrhea, fatigue, decreased appetite

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GLP-1 treatment activates GLP-1 receptors in an area of your brain called the hypothalamus

Here's the clinical summary: Mechanism: GLP-1 receptor agonists can cause nausea-related reduced oral intake and altered skin hydration dehydrated skin is more susceptible to UV damage and less able to repair UV-induced DNA strand breaks Weight loss & UV sensitivity: Significant weight loss (common with GLP-1 medications) can expose areas of skin previously shaded by body fat new UV exposure patterns emerge as body composition changes Drug interaction risk: Many GLP-1 patients are also on metformin, statins, or ACE inhibitors all of which carry independent photosensitivity risks that compound with GLP-1 effects Outdoor exercise motivation: GLP-1 medications often increase motivation for outdoor exercise as energy levels improve patients starting new outdoor routines should simultaneously begin UV protection habits Practical protection priority: For patients using GLP-1 medications for weight management who are increasing outdoor activity, a UPF 50+ umbrella provides consistent, sweat-free UV protection during walks, outdoor exercise, and recreational activities Ozempic & Sun Sensitivity: Expert FAQ Does Ozempic (semaglutide) cause photosensitivity as a direct side effect