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A final decision on whether to add these peptides to the 503A list will come later, following the formal rulemaking process

While direct evidence for Dihexa's effects on neurogenesis remains limited, the HGF/c-Met system that Dihexa activates is known to stimulate stem cell differentiation and promote neurogenesis in the adult hippocampus

( g ) Energy expenditure recorded in metabolic cages (with ANCOVA using BW as covariate) and ( h ) corresponding ambulatory activity ( g , h : CON VEH n = 6, CON acyl-GIP n = 4, Gipr AP-KO n = 6, Gipr AP-KO n = 4)

To evaluate this combination, we used the Zero Interaction Potency (ZIP) model, which accounts for independent drug effects and is particularly suited for combinations of agents with differing targets, such as DPI and vincristine ( Figure 3A )

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, 2016