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In practical terms, decisions depend on knowing how GLP-1 effects intersect with fasting rules, airway protection, and wound or metabolic healing

Injection site reactions, including erythema, pruritus, and nodule formation (particularly with extended-release formulations), occur in approximately 10-20% of patients

Laboratory studies have also shown that GLP-1 receptor activation can reduce reward-seeking behaviors in models exposed to drugs or highly palatable foods, supporting the biological plausibility of these observations (2 Trusted Source The glucagon-like peptide-1 analogue exendin-4 decreases the rewarding value of food and drug rewards

Further research is urgently required in this regard