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Some topical products like hydroquinone or azelaic acid can slow down melanin production, but not as effectively or profoundly as oral tranexamic acid. And oral is the key word here: Though tranexamic acid can be used topically to slow melanin synthesis, clinical studies show it works much more effectively when taken in pill-form

Decreased Long-Chain non-Coding RNA MALAT1 Expression and Increased Hsa-Mir155-3p Expression Involved in Notch Signaling Pathway Regulation in Rheumatoid Arthritis Patients

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10.1002/iub.2008 90