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6.2 Hyperglycemia-induced oxidative stress pathways Glycated hemoglobin (HbA1c), which averages blood sugar levels over the previous two to 3 months within total red blood cell hemoglobin, is a measure of the degree of glucoses natural binding to hemoglobin (glycation)

Quantitative real-time polymerase chain reaction (qRT-PCR) Total RNA was extracted with TRIzol reagent (Ambion, Austin, TX, USA) and reverse-transcribed using PrimeScript RT kit (TaKaRa, Shiga, Japan)

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Pugliese G, Penno G, Natali A et al (2020) Diabetic kidney disease: new clinical and therapeutic issues