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Doses of 500 to 1,000 mg/day of acetyl-L-carnitine have produced increases of sperm count, motility, straight-swimming ability, as well as total normal sperm forms in clinical studies

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Patients on any oral antihyperglycemic agent in monotherapy (N=212) or on a PPAR agent in combination therapy (N=106) or not on an antihyperglycemic agent (off therapy for at least 8 weeks, N=34) were switched to monotherapy with pioglitazone (at a dose of 30-45 mg per day), and completed a run-in period of approximately 12 weeks in duration

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So theres this connection between this molecular process that we knew was really important well, we now know its really important in aging and age-related disease to psychosocial stress