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For example, using single-cell RNA sequencing technology, a precise cell map of TME of patients can be drawn, revealing the interacting cell subpopulations and their specific surface markers in the tumor [264]

The very low rate constants for direct, glutathione-independent dithiol-disulfide exchange reactions between glutaredoxins and roGFP2 or other protein(S 2 )/protein(SH) 2 couples (despite favorable thermodynamics) are a prerequisite and great advantage for reliable redox measurements in vivo

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BMC Complement Med Ther 21(1):101