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The binding of RANKL to its receptor RANK on pre-osteoclasts activates the TNF receptor-associated factor 6 (TRAF6)/NF-B/NFATc1 signaling cascade, thereby promoting osteoclastogenesis and bone resorption

Schedule: Daily subcutaneous injections for 812 weeks (extend to 16 weeks if needed)

The benzyl alcohol acts as a preservative that inhibits bacterial growth, so a single vial can be accessed for multiple withdrawals across a 28-day period rather than being discarded after one use

Lactated Ringers is sometimes described as a balanced crystalloid solution