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142 A dynamic trajectory of brain overgrowth and elevated -catenin signalling has been reported in the developing cerebral cortex in Pten -haploinsufficient mice, highlighting the roles of Pten and -catenin signalling in regulating normal brain growth

Therefore, the administration of H.pylori eradication therapy (which remove H.pylori as a source of ROS) or the micronutrient antioxidants, (vitamin E and/or thioctic acid) may play a basic role in replenishing the depleted micronutrients thus, enhancing ROS removal and decreasing MDA level

Important contraindications exist

In MCF-7 cells, D-I/P@HSA NCs achieved 75% PKM2 silencing efficiency at the mRNA level, significantly inhibiting glycolytic metabolism with a 60% decrease in ATP [114]