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On a molecular level, AOD-9604 is compact enough to achieve good solubility in aqueous diluents yet large enough to retain the structural motif needed for its adipocyte-targeting activity

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We advise against use in patients with active cancer, cardiovascular disease, autoimmune disorders, liver or kidney disease, clotting issues, pregnancy or breastfeeding, or those under age 20

The companies making and selling them are generally difficult to track down or not based in the U.S., which means American authorities have little recourse to enforce standards for quality or legality