glp 1 obesity Glucagon-like peptide in the pathophysiology and pharmacotherapy of clinical Weight loss with GLP-1 medicines

The 5-Amino-1MQ supplied by PeptWorld is produced under rigorous quality control standards and is intended exclusively for researchers, academic institutions, and qualified laboratories

Sustained IGF-1 elevation is a theoretical concern for occult malignancy and for proliferative retinopathy, and most research protocols include a baseline and a 12 week IGF-1 measurement with dose reduction or discontinuation triggers at greater than 2 standard deviations above the age-matched mean

These mechanisms are worth mentioning since if the results in this latest correspondence in the NEJM are indeed replicated, there is a large difference if these effects are occurring either a) Because pancreatic beta cells are dying less b) Because pancreatic beta cells are growing back c) Because pancreatic beta cells are not being targeted by the immune system anymore If replicated, I find a) and b) to be the most likely reasons

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Acknowledgements We are grateful to members of our laboratory for helpful discussion and critical comments on the manuscript