is semaglutide bad for your kidneys Comparative safety and side effects of and tirzepatide: Implications clinical decision-making in obesity management Does Semaglutide Make You Pee

For patients already on injections, this is what the dosage translation looks like: 0.250.5 mg injection start 4 mg or 9 mg pill for 30 days 1.0 mg injection start 9 mg pill for 30 days 1.7 mg injection start 9 mg pill, then titrate to 25 mg after 30 days 2.4 mg injection (max dose) stop injection, wait 7 days, then start 25 mg pill Note: There is *no direct milligram-to-milligram equivalence* between injections and pills

PMID: 37943953, PMCID: PMC10995557, DOI: 10.1513/annalsats.202304-359oc

Zizzari P, He R, Falk S et al (2021) CB1 and GLP-1 receptors cross talk provides new therapies for obesity

In the hypothalamus, GLP-1 receptor agonists activate satiety-promoting POMC/CART neurons while inhibiting hunger-promoting NPY/AgRP neurons

By stimulating receptors in the brain, GLP-1s help you feel full sooner, reduce hunger, and slow down digestion, leading to a significant reduction in calorie intake