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This is due to the dose escalation or titration schedule, where the medication is started at a low dose (e.g., 0.25 mg weekly) and gradually increased every four weeks, if tolerated, until the maintenance dose is achieved

We focus on improving body composition on semaglutide rather than simply achieving weight reduction

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When researchers pool the gold-standard randomized trials, they mostly find little or no effect on overall cancer risk

However, baseline retinopathy was not systematically assessed, and other trials excluding pre-existing retinopathy or maculopathy have reported comparable event rates between treatment groups