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Morrison, Gibson, Vasquez 2017

Preclinical work in rodent models has demonstrated changes in synaptic markers and behavioral improvements on specific learning and memory assays, yet these findings are not directly transferable to humans

Contrary to a popular belief, astrocytes do not, through a specific pre-programmed gain of function, generate a specific toxin(s) or adopt a specific toxic phenotype proposed to be common across many diseases that may represent a universal therapeutic target

These findings correlated with elevated biomarkers of endothelial dysfunction (e.g., ICAM-1, VCAM-1) and pro - thrombotic cytokines [146]

[PubMed]101