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when GSH is taken orally, it has low bioavailability and is easily broken down by the stomach and is not effective
Chronic glutathione depletion confers protection against alcohol-induced steatosis: implication for redox activation of AMP-activated protein kinase pathway
They suggest a half dose in the morning and a half and night, which reduces stomach sensitivity, for people who have severe pigmentation and those who are recommended higher doses
doi:10.1016/0003-9861(92)90035-U
The exogenous induction of GSH depletion causes mitochondrial-dependent apoptosis in CYP2E1-expressing HepG2 cells (E47 cells) [123]
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