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Burden of depressive disorders by country, sex, age, and year: findings from the global burden of disease study 2010

For example, Vitamin D deficiency may reduce intestinal calcium absorption, causing gut stasis and subsequent IPC, which would allow gut microbiota to transfer more endotoxins into the blood and trigger inflammatory cytokines production within the CNS (249)

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This proposed mechanism has been directly validated in animal models where the surgically severed vagus nerve attenuated anxiety- and depression-like behaviors in mice after oral antibiotic administration, providing direct evidence for neuropsychiatric effects induced by antibiotics through the gutbrain axis (Joo et al., 2023)