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The EVOKE result is consistent with this logic: semaglutide is a large, acylated molecule with poor brain penetrance, and it did not show benefit in Alzheimers disease

Nibber A, Singh H, Burnet P, Lennox B, Minichino A

For weight management, being overweight alone isnt always enough for insurance companies to cover GLP1 drugs

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May influence gene expression related to repair processes