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Tirzepatide acts directly on appetite signalling by activating GLP-1 and GIP receptors, increasing satiety, slowing gastric emptying and enhancing insulin secretion

Therefore, the effective therapy of many neurodegenerative disorders of the central nervous system (CNS) such as Parkinsons disease (PD) or Alzheimers disease (AD) remains a serious challenge

doi: 10.3389/fendo.2023.1326546 4 FurukawaSFujitaTShimabukuroMIwakiMYamadaYNakajimaYet al

This suggests that other dietary factors, outside of glutamate, such as the increased consumption of antioxidants and micronutrients protective against excitotoxicity, may either alternatively be responsible for the widespread improvement in psychiatric symptoms observed in this study, and/or may be protecting against negative effects from glutamate exposure during the challenge period

[DOI] [PubMed] [Google Scholar] Fiorentini C, Busi C, Gorruso E, Gotti C, Spano P, Missale C (2008) Reciprocal regulation of dopamine D1 and D3 receptor function and trafficking by heterodimerization