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However, GI AE are usually mild-to-moderate, transient, partially preventable, and rarely lead to treatment discontinuation 107

less water concentrates the peptide for larger doses

10.1111/j.1346-8138.2003.tb00356.x 139 YuR.BroadyR.HuangY.WangY.YuJ.GaoM.et al (2012)

The development of oral glucagon like peptide 1 analogs offers a transformative opportunity to enhance patient convenience, improve compliance, and expand the target demographic, particularly among individuals with needle aversions or injection phobia

Clinical trials show average weight loss of 50+ pounds over 3-6 months, with continued gradual loss possible over longer treatment periods