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[2] Nou, V., Inoue, H., Lee, H

They found that the increases of HR, SBP and sympathetic activity seen in such settings were not accompanied by any changes in total peripheral resistance

While XR formulations might provide more stable appetite suppression, they: Still aren't FDA-approved for weight loss Carry the same risks as IR formulations Are even more expensive Provide no proven advantage for weight management Are there genetic tests to predict response to these medications

Shah shares , Surgery helps people lose around 25 to 30% of their total weight, whereas medication is around 15 to 20%. He notes that surgery has a longer track record with data showing 80% of patients maintain weight loss long term. For GLP-1 medications, the long-term data is still developing

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