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Richards et al., 2014)

This activation serves to improve mood, relieve pain, and reduce inflammation

The TMAO treatment induced the hypertrophy of cultured cardiomyocytes and expression of hypertrophic markers such as atrial natriuretic peptide (ANP) and beta-myosin heavy chain (-MHC) that was demonstrated to be mediated via TGF-/Smad3 signaling that had been identified in the development of cardiac hypertrophy and fibrosis