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This nutrient can also be taken orally, but as an antioxidant, it is vulnerable to damage from stomach acid, so binding forms of glutathione, such as liposome glutathione, have been developed

Many users find this dose sufficient for significant improvement

Higher-dose oral B12 (e.g., 1000 g daily) is sometimes used but should only be considered under clinical supervision with appropriate monitoring, particularly in cases of malabsorption where intramuscular treatment remains the first-line approach in UK practice

Physiol Rev 91:14471531 Schoeman EM, van der Westhuizen FH, Erasmus E et al (2017) Clinically proven mtDNA mutations are not common in those with chronic fatigue syndrome