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The high sensitivity (100% for the known carcinogenic and mutagenic NAs tested here) of HepG2 cells supplemented with hamster S9-mix, as compared to PHH and PRH, in principle might make this system a valuable tool for hazard identification and potential follow up of negative/borderline EAT test results to provide further reassurance for the EAT result

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Finally, nine articles that investigated the current knowledge on substances that have or may affect the brain at the cognitive level in the context of sports were included in the review